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As described herein and as known in the art, to operatively link the first and second polypeptides of a fusion protein, typically nucleotide sequences encoding the first and second polypeptides are ligated to each other in-frame to create a chimeric gene encoding the fusion protein. Studies looked at a wide range of pharmacologic interventions including antispasmodics, depo medrol costo first anticholinergic/barbiturate combinations, antidepressants, bulking agents, dopamine antagonists, carminatives, opioids, tranquilizers, phenytoin, timolol, and diltiazem.
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